physician photo

Tiffany M. Osborn, MD, MPH, FACEP

  • Associate Professor of Surgery

Medical School

MD, University of Texas Health Science Center, San Antonio, TX, 1997

Graduate School

Masters in Public Health (Research Track), London School of Hygiene and Tropical Medicine, London, England, 2007-2009

Post Doctoral Education

Residency, Emergency Medicine, University of Maryland Medical System, Baltimore, MD, 2000

Fellowship, Trauma and Surgical Critical Care, R Adams Cowley Shock Trauma Center, Baltimore, MD, 2002

Board Certifications

Emergency Medicine -- Certified
European Society of Intensive Care Medicine - Critical Care -- Certified

Honors and Awards

Fellowship in American College of Emergency Physicians, 2006

Society of Critical Care Medicine: Innovative Research Award, “Epidemiology of Sepsis in Trauma,” 2002

Emergency Medicine Residents' Association Dedication Award, 2000

Research Interests

Principal Investigator: "Sepsis Biomarker Study," Biosite, 2005-2006

Trial Clinician: "Protocolised Management in Sepsis (ProMISe)," National Health System; UK, 2009-2014

Hospital Affiliations

Barnes-Jewish Hospital

Selected Publications

Osborn TM, Phillips G, Lemeshow S, Townsend S, Schorr CA, Levy MM, Dellinger RP. Sepsis severity score: an internationally derived scoring system from the surviving sepsis campaign database*. Crit Care Med. 2014 Sep;42(9):1969-76.

Ginde AA, Blatchford PJ, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Rivers EP, Shapiro NI. Age-related differences in biomarkers of acute inflammation during hospitalization for sepsis. Shock 2014 Aug;42(2):99-107.

Ferrer R, Martin-Loeches I, Phillips G, Osborn T, Townssend S, Dellinger RP, Artigas A, Schorr C, Levy MM. Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour: Results From a Guideline-Based Performance Improvement Program. Crit Care Med 2014 Mar;18:47.

Power GS, Harrison DA, Mouncey PR, Osborn TM, Harvey SE, Rowan KM. The Protocolised Management in Sepsis (ProMISe) trial statistical analysis plan. Crit Care Resusc. 2013 Dec;15(4):311-7.

Osborn TM, Levy M, Dellinger RP, Annane D. The Surviving Sepsis Campaign Author Reply. Crit Care Med. 2013 Oct;41(10):e293-4.

ProCESS/ARISE/ProMISe Methodology Writing Committee, Huang DT, Angus DC, Barnato A, Gunn SR, Kellum JA, Stapleton DK, Weissfeld LA, Yealy DM, Peake SL, Delaney A, Bellomo R, Cameron P, Higgins A, Holdgate A, Howe B, Webb SA, Williams P, Osborn TM, Mouncey PR, Harrison DA, Harvey SE, Rowan KM. Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE and ProMISe. Intensive Care Medicine. 2013. Oct;39(10):1760-75.

Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, Osborn TM, Nunnally ME, Townsend SR, Reinhart K, Kleinpell RM, Angus DC, Deutschman CS, Machado FR, Rubenfeld GD, Webb SA, Beale RJ, Vincent JL, Moreno R; and the Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock 2012. Critical Care Med 2013 Feb;41(2):580-637.

Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, Vincent JL, Townsend S, Lemeshow S, Dellinger RP. Outcomes of the Surviving Sepsis Campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis. 2012 Dec;12(12):919-24.

Casserly B, Gerlach H, Phillips GS, Gemeshow S, Marshall JC, Osborn TM, Levy MM. Low dose steroids in adult septic shock: Results of the Surviving Sepsis Campaign. Intensive Care Med. 2012 Dec;38(12):1946-54.

Perman SM, Chang AM, Hollander JE, Gaieski DF, Trzeciak S, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Goyal M, Cairns CB, Ngo L, Rivers EP, Shapiro NI. Relationship between B-type natriuretic peptide and adverse outcome in patients with clinical evidence of sepsis presenting to the emergency department. Acad Emerg Med. 2011 Feb;18(2):219-22.

Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, Gaieski DF, Goyal M, Cairns CB, Kupfer K, Lee SW, Rivers EP. The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med. 2010 Jul;56(1):52-59.

Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson KJ, Milzman D, Gaieski DF, Goyal M, Cairns CB, Ngo L, Rivers EP. A prospective, multi-center derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsis. Crit Care Med. 2009;37(1):96-104 10.

Dellinger, RP et al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2008. Crit Care Med. 2008 36(1):296-327. (Guidelines writing committee listed p. 327)

Otero RM, Nguyen HB, Huang DT, Gaieski DF, Goyal M, Gunnerson KJ, Trzeciak S, Sherwin R, Holthaus CV, Osborn T, Rivers EP. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest Nov. 2006;130(5):1579-95.

Nguyen HB, Rivers EP, Abrahamian FM, Moran GJ, Abraham E, Trzeciak S, Huang DT, Osborn T, Stevens D, Talan DA. Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med. 2006 Jul;48(1):28-54.

Pub Med page for Tiffany M. Osborn, MD, MPH

Books

Deblieux P, Osborn TM (eds.). Critical Care in Emergency Medicine.  Emergency Medicine Clinics of North America. August 2008:26(3).

Editorial Positions

Journal Editor

2006-2010, Associate Editor, Journal Watch Emergency Medicine – part of MMS/ NEJM

Journal Reviewer

2005-Present, Annals of Emergency Medicine

2006-Present, Critical Care Medicine

Chapters

Rivers EP, Nguyen HB, Osborn TM, et al. Early Goal-Directed Therapy in Severe Sepsis and Septic Shock. 25 Years of Progress and Innovation in Intensive Care Medicine. 2008. European Society of Intensive Care Medicine, pp. 383-391.

Osborn TM, Alagappan K, Emlet L, et al. The Patient Care Continuum. From the Emergency Department to the Intensive Care Unit. 25 Years of Progress and Innovation in Intensive Care Medicine. 2008. European Society of Intensive Care Medicine, pp. 189-197.