physician photo

Anja G. Fuchs, PhD

  • Research Assistant Professor

Graduate School

M.Sc., Immunolgy and Immunogenetics, University of Manchester, Manchester, United Kingdom, 2001

Ph.D., Immunology, University of Manchester, Manchester, United Kingdom, 2006

Post Doctoral Education

Postdoctoral Research Associate, Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 2008

Postdoctoral Research Associate, Divsion of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 2010

Honors and Awards

2005, Travel Award, Keystone Symposium "Innate Immunity of Pathogens", Keystone Symposia/National Institutes of Health

2005, Travel Award, 9th Annual Meeting of the Society for Natural Immunity, Society for Natural Immunity

2007, Travel Award, 11th European Meeting on Cmplement in Human Disease

Research Interests

Innate immune mechanisms that are at play in response to trauma and sepsis.

Selected Publications

Czajkowsky DM, Andersen JT, Fuchs A, Wilson TJ, Mekhaiel D, Colonna M, He J, Shoa Z, Mitchell DA, Wu G, Dell A, Haslam S, Lloyd  KA, Moore SC, Sandlie I, Blundell PA, Pleass RJ. Developing the IVIG biomimetic, Hexa-Fc, for drug and vaccine applications. Sci Rep. 2015 Apr 27;5:9526.

Robinette ML, Fuchs A, Cortex VS, Lee JS, Wang Y, Durum SK, Gilfillan S, Colonna M; the Immunological Genome Consortium. Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets. Nat Immunol. 2015 Mar;16(3):306-17.

Lai H, He J, Hurtado J, Stahnke J, Fuchs A, Mehlhop E, Gorlatov S, Loos A, Diamond MS, Chen Q. Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants. Plant Biotechnol. J. 2014; 12: 1098-1107.

Cortez VS, Fuchs A, Cella M, Gilfillan S, Colonna M. Cutting edge: salivary gland NK cells develop independently of nfil3 in steady-state. J. Immunol. 2014; 192: 4487-4491.

Fuchs A, Colonna M. Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumors of the gastrointestinal tract. Curr. Opin. Gastroenterol. 2013; 29: 581-587. (review)

Gmyrek GB, Akilesh HM, Graham DB, Fuchs A, Yang L, Miller MJ, Sandoval GJ, Sheehan KC, Schreiber RD, Diamond MS, Swat W. Loss of DAP12 and FcRg drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS One. 2013; 8:e76145.

Fuchs A, Vermi W, Lee JS, Lonardi S, Gilfillan S, Newbery RD, Cella M, Colonna M. Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12 and IL-15-responsive IFN- -producing cells. Immunity. 2013; 38: 761-781.

Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology. 2013; 145: 366-374.

Wilson TJ, Fuchs A, Colonna M. Cutting Edge: Human FcRL4 and FcRL5 are receptors of IgA and IgG. J. Immunol. 2012; 188: 4741-4745.

Fuchs A, Colonna M. Natural Killer (NK) and NK-like cells at mucosal epithelia: Mediators of anti-microbial defense and maintenance of tissue integrity. Eur. J. Microbiol. Immunol. 2011; 4: 257-266. (review)

Fuchs A, Pinto AK, Schwaeble WJ, Diamond MS. The lectin pathway of complement activation contributes to protection from West Nile virus infection. Virology. 2011; 412: 101-109.

Cardone J, Le Friec G, Vantourout P, Roberts A, Fuchs A, Jackson I, Suddason T, Lord G, Atkinson JP, Cope A, Hayday A, Kemper C. Complement regulator CD46 temporarally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 2010; 11: 862-871.

Dunay IR, Fuchs A, Sibley LD. Inflammatory monocytes but not neurtophils are necessary to control infection with Toxoplasma gondii in mice. Infect. Immun. 2010; 78: 1564-1570.

Fuchs A, Lin TY, Beasley DW, Stover CM, Schwaeble WJ, Pierson TC, Diamond MS. Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin. Cell Host Microbe. 2010; 8: 186-195.

Avirutnan P, Fuchs A, Hauhart RE, Somnuke P, Youn S, Diamond MS, Atkinson JP. Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J. Exp. Med. 2010; 207: 793-806.

Pub Med page for Anja G. Fuchs, PhD

Editorial Positions

Journal Reviewer

2012-Present, Journal if Virology

2012-Present, European Journal of Immunology

2012-Present, PLOS One

2012-Present, Tissue Antigens

Editorial Positions

2012-Present, Editor-in-Chief, European Journal of Microbiology and Immunology