physician photo

Bradley D. Freeman, MD

  • Professor of Surgery

Medical School

Duke University, 1988

Post Doctoral Education

Internal Medicine - Duke University Medical Center, 1988-1991

General Surgery - Washington University Medical Center, 1991-1997

Critical Care - National Institutes of Health, 1993-1995

Board Certifications

General Surgery, Internal Medicine, and Critical Care Medicine

Clinical Interests

Dr. Freeman specializes in elective and emergency general surgery and trauma.

Research Interests

NIGMS, AHRQ, American College of Surgeons
Ethical considerations in the application of genetic technology to the care of the critically ill patient, use of clinical simulation in teaching and assessing clinical competency, and optimizing use of tracheostomy in the setting of acute respiratory failure.

Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Surgical and Wound Care Clinic
Barnes Center for Outpatient Health
4901 Forest Park Ave.
Floor 3, Suite 340
St. Louis, MO 63108
Fax: 314-362-5743

Contact Information

Barnes - Jewish Hospital
One Barnes-Jewish Hospital Plaza, Suite 14107
St. Louis, MO 63110
(314) 362-1064

Selected Publications

Freeman BD, Kennedy CR, Frankel HL, Clarridge B, Bolcic-Jankovic D, Iverson E, Shehane E, Celious A, Zehnbauer B, Buchman TG. Ethical considerations in the collection of genetic data from critically ill patients: what do published studies reveal about potential directions for future research? Pharmacogenomics Journal. 2010;10:77-85.

Hamilton N, Freeman BD, Woodhouse J, Ridley C, Murray D, Klingensmith ME. Team behavior during trauma resuscitation: A simulation-based performance assessment. Journal of Graduate Medical Education. 2009 Dec.;253-259.

Freeman BD, Kennedy C, Coopersmith CM, Buchman TG. Examination of non-clinical factors affecting tracheostomy practice in an academic surgical intensive care unit. Critical Care Medicine. 2009;37;3070-3078.

Freeman BD, Kennedy CR, Robertson TE, Coopersmith CM, Schallom L, Sona C, Cracchiolo L, Schuerer DJE, Boyle WA, Buchman TG. Tracheostomy protocol: Experience with development and potential utility. Critical Care Medicine. 2008 June;36(6):1742-1748.

Freeman BD, Dixon DJ, Coopersmith CM, Zehnbauer BA, Buchman TG. Pharmacoepidemiology of QT-prolonging drug administration in critically ill patients. Pharmacoepidemiology and Drug Safety. 2008;17(10):971-981.

Freeman BD. Is there a hidden benefit of early tracheostomy? Critical Care Medicine. 2008;36(9):2688-2689.

Minei JP, Nathens AB, West M, Harbrecht BG, Moore EE, Shapiro MB, Bankey PE, Johnson JL, Freeman B, McKinley BA, Moore FA, Maier RV. Inflammation and the Host Response to Injury Large Scale Collaborative Research Program Investigators. Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. II. Guidelines for prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP) in the trauma patient. [Journal Article. Multicenter Study. Practice Guideline] Journal of Trauma-Injury Infection & Critical Care. 2006;60(5):1106-1113; discussion 1113.

Moore FA, McKinley BA, Moore EE, Nathens AB, West M, Shapiro MB, Bankey P, Freeman B, Harbrecht BG, Johnson JL, Minei JP, Maier RV. Inflammation and the Host Response to Injury, a large-scale collaborative project: patient-oriented research core--standard operating procedures for clinical care. III. Guidelines for shock resuscitation. [Review] [25 refs] [Journal Article. Review] Journal of Trauma-Injury Infection & Critical Care. 2006;61(1):82-89.

West MA, Shapiro MB, Nathens AB, Johnson JL, Moore EE, Minei JP, Bankey PE, Freeman B, Harbrecht BG, McKinley BA, Moore FA, Maier RV. Inflammation and the Host Response to Injury, a large-scale collaborative project: Patient-oriented research core-standard operating procedures for clinical care. IV. Guidelines for transfusion in the trauma patient. [Journal Article] Journal of Trauma-Injury Infection & Critical Care. 2006;61(2):436-439.

Freeman BD, Kennedy CR, Coopersmith CM, Zehnbauer BA, Buchman TG. Genetic research and testing in critical care: surrogates’ perspective. Critical Care Medicine. 2006; 34:4:986-994. (See accompanying editorial: Lavery JV and Slutsky AS. Substitute decisions about genetic testing in critical care research: a glimpse behind the curtain. Critical Care Medicine. 2006;34:4:1257-1259.)

Freeman BD, Borecki IR, Coopersmith CM, Buchman TG. Relationship between tracheostomy timing and duration of mechanical ventilation in critically ill patients. Critical Care Medicine. 2005;33:2513-2520. (See accompanying editorial: Ferguson ND. Tracheostomy for ventilated patients – not when but in whom? Critical Care Medicine. 2005;33:2695-2696.)

Freeman BD and McLeod HL. Challenges of implementing pharmacogenetics in the critical care environment. Nature Reviews Drug Discovery. Volume 3:88-93 (January 2004).

Freeman BD, Buchman TG, Zehnbauer BA. Template-directed dye-terminator incorporation with fluorescence polarization detection (TDI-FP) for analysis of single nucleotide polymorphisms (SNP) associated with cardiovascular and thromboembolic disease. Thrombosis Research. 2003;111:373-379.

Rafii Tabrizi A, Zehnbauer BA, Borecki IB, Buchman TG, McGrath SD, Freeman BD. The frequency and effects of Cytochrome P450 (CYP) 2C9 polymorphisms in patients receiving warfarin. Journal of the American College of Surgeons. 2002;194:267-273.

Freeman BD, Isabella K, Cobb JP, Boyle WA, Schmieg RE, Kolleff MH, Lin N, Saak T, Thompson EC, Buchman TG. A prospective randomized study comparing percutaneous and surgical tracheostomy in critically ill patients. Critical Care Medicine. 2001;29:926-930.

Freeman BD, Danner RL, Banks S, Natanson C. Safeguarding patients in clinical trials with high mortality rates. American Journal of Respiratory and Critical Care Medicine. 2001;164:190-192.


Freeman BD. Indications for and Management of Tracheostomy. In: Abraham E et al. (eds.). Textbook of Critical Care. 5th edition. Philadelphia: W.B. Saunders Co. (in press)

Freeman BD: Fluid and Electrolyte Abnormalities. In: Mulholland M, Doherty GM (eds.). Complications in Surgery. 2nd edition. Philadelphia: Lippincott, Williams and Wilkins. (in press)

Freeman BD Commentary on "Genetic Influence on Response and Outcome" by O’Keefe, GE. In: Feliciano, Mattox, Moore (eds.). Trauma. New York: McGraw Hill, Inc.; 2008.

Freeman BD, Banks S, Natanson C. Using Secondary Data in Statistical Analysis. In: Gallin J (ed.). Principles and Practices in Clinical Research. 2nd edition. Academic Press; 2007.

Freeman BD, Natanson C. Hypotension, Shock, and Multiple Organ Dysfunction. In: Wachter RM, Goldman L, Hollander H (eds.). Hospital Medicine. 2nd edition. Baltimore: Williams & Wilkins; 2005.