Grant Bochicchio

Grant V. Bochicchio, MD, MPH

  • Chief, Acute and Critical Care Surgery
  • Edison Professor of Surgery

Medical School

MD, The Pennsylvania State University College of Medicine, Hershey, PA, 1993

Graduate School

MPH, Health Administration and Epidemiology,
University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 1989

Post Doctoral Education

Intern in Surgery, Pennsylvania State University Hospital, Hershey, PA, 1993-94

Resident in Surgery, Pennsylvania State University Hospital, Hershey, PA. 1994-98

Fellowship in Trauma and Critical Care, Department of Surgery, University of Maryland and R Adams Cowley Shock Trauma Center, Baltimore, MD, 1998-99

Board Certifications

General Surgery -- Certified
Surgical Critical Care -- Certified

Honors and Awards

University of Maryland, Baltimore, “Inventor of the Year,” “Nanotechnology,” 2009

Surgical Infection Society Faculty Award for Research on Ventilator Associated Pneumonia, competitive national award, 2004-2005

R Adams Cowley Shock Trauma Center Gala Hero Award, 2001, ‘04, ‘10

US Army Special Operations Command Award for Excellence in Teaching, 2000-2004

International Sepsis Forum Traveling Fellowship Award, 2000

Clinical Interests

Trauma and emergency surgery, minimally invasive and hepatobiliary surgery, surgical critical care

Research Interests

Principal Investigator: "Open versus Laparoscopic Hernia Repair," National Veterans Administration Cooperative Study, 2000-2004

Principal Investigator: "Long-Term Outcome of Inguinal Hernia Surgery Registry. Open versus Laparoscopic Hernia Repair," National Veterans Administration and American College of Surgeons, 2004-2005.

Principal Investigator: "Metabonomics in Trauma Patients," University of Connecticut, 2004-2007.

Co-Principal Investigator: "Trauma Team Training," United States Air Force, 2005-2007.

Principal Investigator: "Infection Control Strategies to Reduce Colonization and Infection Caused by Anti-microbial Resistant Bacteria in Adult Intensive Care Units," National Institute of Allergy and Infectious Disease, 2005-2008.

Principal Investigator: "Randomized, Multi-Center, Comparative Trial of Short-Course Empiric Antibiotic Therapy versus Standard Antibiotic Therapy for Subjects with Pulmonary Infiltrates in the Intensive Care Unit (ICU)," National Institute of Allergey and Infectious Disease, 2006-2008.

Principal Investigator: "Evaluation of ClotFoam in a Rat Model," Maryland Techonology Development Corporation, 2007-2008.

Program Mentor: T32 Training Grant (Hirshon, JM - PI) University of Maryland, National Institutes of Health, 2007-2010.

Principal Investigator: "Tight Glycemic Control in Critically Injured Trauma Patients," United States Air Force, 2007-2010.

Principal Investigator: “A Prospective Observational Study Evaluating FLEX-HD in Complicated Ventral Hernia Repair,” Musculoskeletal Transplant Foundation, 2007-2010

Co-Principal Investigator: “Blast Injury in Traumatic Brain Injury: Animal Model and Human Volunteer Safety Study,” United States Congressional TBI Fund, 2008-2011.

Principal Investigator: “Biomarkers as a Predictor of Wound Closure,” Office of Naval Research, 2011-2012.

Principal Investigator: “Team Vista”, Department of Veterans Affairs, Greenfield Project, 2010-2012.

Principal Investigator: “Clotfoam Non-Compressible Hemostat,” Department of Defense CDRMP, 2010-2012.

Principal Investigator: "Glyburide Health Volunteer Study," Department of Defense Army Medical Research and Material Command, 2013-2014.

Principal Investigator: "Efficacy of 3-Row Stapler in Lung Resections in Trauma," United States Surgical, 2000-2002.

Principal Investigator: "Efficacy of Costasis Surgical Hemostat in Trauma," Cohesion Technologies, 2000-2002.

Principal Investigator: "Methicillin-resistant Staphylococcus Aureus Acquisition in the Trauma Population," BMS Pharmaceuticals, 2001-2003

Principal Investigator: "Impact of Nosocomial Infections in Trauma," Wyeth Pharmaceuticals, 2001-2005.

Principal Investigator: "PREVENT Study," Merck Pharaceuticals, 2002-2003.

Principal Investigator: "Impact of Johns Hopkins ABX Guide on Critical Care Education. A Randomized Prospective Study," Johnson and Johnson, 2002-2003.

Principal Investigator: "Intra-abdominal infection study, Multi-Institutional Study," Merck Pharmaceuticals, 2003-2006.

Principal Investigator: "Medical Center Case Control Study to Collect Plasma and Whole Blood from ICU Patients at Risk of Sepsis to Identify Biological Markers to Predict Sepsis," BD Diagnostics, 2003-2007.

Principal Investigator: "Topical Use of Blood Products and Sealants," American Red Cross. 2004-2005.

Principal Investigator: "VAP in Trauma Patients," Surgical Infection Society, 2004-2006.

Principal Investigator: "Ventilator Associated Pneumonia Study. Comparison of Doripenem versus Meropenem in Pneumonia Patients," Peninsula Pharmaceuticals, 2004-2007.

Principal Investigator: "EPO-ICU-002 Study: Comparison of Erythropoietin Alpha versus Placebo in Critically Ill Patients," Johnson and Johnson, 2004-2007.

Principal Investigator: "Evaluating Efficacy and Long Term Thrombotic Effects of a Fibrin Bandage in a Swine Model," Johnson and Johnson, 2006-2007.

Principal Investigator: "A Prospective Study to Evaluate the Erythropoietic Responsiveness Associated with Once Weekly (QW) Administration of Darbepoetin Alfa (ARANESP) in Patients Admitted to the Intensive Care Unit," Amgen, 2006-2007.

Principal Investigator: "Evaluation of the Susceptibility of Porcine Submucosa to Various Pathogens (In-Vitro)," Cook Biotech, 2006-2007.

Principal Investigator: "A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effect of Recombinant Human Erythropoietin (EPOETIN ALFA; PROCRIT), on Function Outcomes in Anemic, Critically Ill, Trauma Subjects," Ortho Biotech, 2006-2009.

Principal Investigator: "Ventilator Associated Pneumonia," Ortho McNeil and Johnson and Johnson, 2007-2008.

Principal Investigator: "Post-Operative Ileus," Wyeth & Tranzyme, 2007-2008.

Principal Investigator: "A Randomized, Double-Blind, Placebo-Controlled, Phase- 2 Study to Assess the Safety and Efficacy Effects of ART-123 on Subjects with Sepsis and Disseminated Intravascular Coagulation," Artisan Pharma, 2007-2008.

Principal Investigator: "Evaluation of Safety and Efficacy of a Fibrin Patch in Soft Tissue Bleeding, A Randomized, Prospective Trial," Johnson and Johnson, 2008-2009.

Principal Investigator: "Evaluating Safety and Efficacy of a Continuous Glucose Monitor," Edwards Life Sciences, 2009-2010.

Principal Investiagor: "Dori-3008 VAP Study," Johnson and Johnson, 2009-2011.

Principal Investigator: "Abthera Open Abdomen Study," KCI, 2009-2012.

Principal Investigator: "Ring, Inguinal Hernia Study," LifeCell, 2009-2012.

Principal Investigator: "Prism, Parastomal Hernia Prevention Study," LifeCell, 2009-2012.

Government - Principal Investigator: "A Randomized Trial of Supplemental Parenteral Nutrition in Under and Overweight Critically Ill Patients: The TOP UP Trial," National Institutes of Health/DHHS, 2013-PRESENT.

Foundation - Principal Investigator: "The Effects of Infection on Hernia Repair Meshes," Barnes Jewish Hospital Foundation, 2013-PRESENT.

Foundation - Principal Investigator: "A Randomized, Prospective, Double-blind, Multi-Center Study to Examine and Compare the Outcomes Associated with the Use of Flex HD, a Human Acellular Dermal Matrix, and Strattice, a Porcine Acellular Dermal Matrix Allograft, When Used as a Reinforcing Material in the Repair of Large Abdominal Wall Hernias by a Component Separation Technique," Musculoskeletal Transplant Foundation, 2013-PRESENT.

Industry - Principal Investigator: "A Non-Investigational Post-Market Trial Using EVARREST Fibrin Sealant Patch as an Adjunct to Hemostasis in Soft Tissue Bleeding During Intra-Abdominal, Retroperitoneal, Pelvic and Non-Cardiac Throacic Surgery," Ethicon, 2013-PRESENT.

Government - Principal Investigator: "A Phase 1, Single-Arm Study Evaluating ClotFoam as an Adjunct Hemostasis in Abdominal Surery in Which Liver Bleeding is Encountered," National Institutes of Health/NHLBI, 2014-PRESENT.

Government - Co-Principal Investigator: "Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury (TAMPITI Trial)," US Army Medical Research Acquisition Acitivity, 2014-PRESENT.

Government - Principal Investigator: "Recombinant Interleukin-12, a Broad Spectrum Biologic for the Treatment of Battle and Traumatic Wound Infections," Department of Defense, 2014-PRESENT.

Industry - Principal Investigator: "Wound Care Proposal," Cook Biotech, 2014-PRESENT.

Industry - Principal Investigator: "Hemodynamic Instability Rules Based Advisor: The Impact to Care with a New Predictive Indicator," Philips, 2014-PRESENT.

Industry - Principal Investigator: "Manual versus Automated Monitoring Accuracy of Glucose IDE (Manage IDE)," Optiscan, 2014-PRESENT.



Hospital Affiliations

Barnes-Jewish Hospital

Patients Seen At

Surgical and Wound Care Clinic
Barnes Center for Outpatient Health
4901 Forest Park Ave.
Floor 3, Suite 340
St. Louis, MO 63108
Fax: 314-362-5743

Selected Publications

Nohra E, Bochicchio GV. Management of the Gastrointestinal Tract and Nutrition in the Geriatric Surgical Patient. Surg Clin North Am. 2015 Feb;95(1):85-101.

Bochicchio G, Gupta N, Porte RJ, Renkens KL, Pattyn P, Topal B, Troisi RI, Muir W, Chetter I, Gillen DL, Zuckerman LA, Frohna PA. The FINISH-3 Trial: A Phase 3, International, Randomized, Single-Blind, Controlled Trial of Topical Fibrocaps in Intraoperative Surgical Hemostasis. J Am Coll Surg. 2015 Jan;220(1):70-81.

Bochicchio GV, Jain A, McGonigal K, Turner D, Ilahi O, Reese S, Bochicchio K. Biologic vs. Synthetic Inguinal Hernia Repair: 1-Year Results of a Randomized Double-Blinded Trial. J Am Coll Surg. 2014 Apr;201(4):751-7.

Bochicchio GV, De Castro GP, Bochicchio KM, Weeks J, Rodriguez E, Scalea TM. Comparison study of acellular dermal matrices in complicated hernia surgery. J Am Coll Surg. 2013 Oct;217(4):606-13.

Fischer CP, Bochicchio G, Shen J, Patel B, Batiller J, Hart JC. A prospective randomized, controlled trial of the efficacy and safety of fibrin pad as an adjunct to control soft tissue bleeding during abdominal, retroperitoneal, pelvic, and thoracic surgery. J Am Coll Surg. 2013 Sep;217(3):385-93.

Cheatham ML, Demetriades D, Fabian TC, Kaplan MJ, Miles WS, Schreiber MA, Holcomb JB, Bochicchio G, Sarani B, Rotondo MF. Prospective study examining clinical outcomes associated with a negative pressure wound therapy system and Barker's vacuum packing techniques. World J Surg. 2013 Sep;37(9):2018-30.

Winfield RS, Bochicchio GV. The critically injured obese patient: a review and a look ahead. J Am Coll Surg. 2013 Jun;216(6):1193-206

Park H, Kent J, Joshi M, Zhu S, Bochicchio GV, Henry S, Scalea T. Percutaneous versus open tracheostomy: comparison of procedures and surgical site infection. Surg Infect (Larchmt). 2013 Feb;14(1):21-3.

Bochicchio G. Preoperative glycemic control in bariatrics and colorectal surgical patients. Ann Surg. 2013 Jan;257(1):15-6.

Crook DW, Walker AS, Kean Y, Weiss K, Cornely OA, Miller MA, Esposito R, Louie TJ, Stoesser NE, Young BC, Angus BJ, Gorbach SL, Peto TE; Study 003/004 Teams. Fidaxomicin versus vancomycin for clostridium difficile infection: meta-analysis of pivotal randomized controlled trials. Clin Infect Dis. 2012 Aug;55 Suppl 2:S93-103.

De Castro GP, Dowling MB, Kilbourne M, Keledjian K, Driscoll IR, Raghavan SR, Hess JR, Scalea TM, Bochicchio GV. Determination of efficacy of novel modified chitosan sponge dressing in a lethal arterial injury model in swine. J Trauma Acute Care Surg. 2012 Apr;72(4):899-907.

Stein DM, Lindell AL, Murdock KR, Kufera JA, Menaker J, Bochicchio GV, Aarabi B, Scalea TM. Use of serum biomakers to predict cerebral hypoxia after severe traumatic brain injury. J Neurotrauma. 2012 Apr 10;29(6):1140-9.

Krinsley J, Bochicchio K, Calentine C, Bochicchio G. Glucose measurement of intensvie care unit patient plasma samples using a fixed wavelength mid-infrared spectroscopy system. J Diabetes Sci Technol. 2012 Mar 1;6(2):294-301.

Bochicchio G, Charlton P, Pezzullo JC, Kosutic G, Senagore A. Ghrelin agonist TZP-101/ulimorelin accelerates gastrointestinal recovery independently of opiod use and surgery type: covariate analysis of phase 2 data. World J Surg. 2012 Jan;36(1):39-45.

Kuehn R, Simard PF, Driscoll I, Keledjian K, Ivanova S, Tosun C, Williams A, Bochicchio G, Gerzanich V, Simard JM. Rodent model of direct cranial blast injury. J Neurotrauma. 2011 Oct;28(10):2155-69.

Pub Med page for Grant V. Bochicchio, MD, MPH

Editorial Positions

Journal Reviewer

2002-present, Journal of Surgical Research
2003-present, Critical Care Medicine
2003-present, Infections in Medicine
2003-present, Surgical Infections
2005-present, Journal of Trauma
2005-present, Journal of the American College of Surgeons
2007-present, Transfusion
2008-present, Archives of Surgery


Bochicchio G. Retroperitoneal Injury in Trauma. In: Current Therapy of Trauma and Surgical Critical Care. In press, 2007.

Bochicchio G, Scalea T. Hyperglycemia in Surgery. In: Current Therapy of Trauma and Surgical Critical Care; 2008.

Bochicchio G, Scalea TM. Surgical Anatomy of the Abdomen and Regroperitoneum. In: Current Therapy of Trauma and Surgical Critical Care; 2008.

Bochicchio G. Unique Trauma Populations: Obese, Elderly, Pregnant, Adolescent. In: Trauma Surgical Critical Care and Surgical Emergencies; 2008.

Bochicchio G, Scalea T. Glycemic Control in the ICU. In: Advances in Surgery; 2010.