physician photo

Forest R. Sheppard, MD

  • Associate Professor of Surgery

Medical School

University of Virginia School of Medicine, Charlottesville, Virginia, 1998

Post Doctoral Education

General Surgery Residency, University of Colorado Health Sciences Center, Denver, Colo., 1998-2005

Trauma and Surgical Critical-Care Fellowship, Denver Health Medical Center & University of Colorado Hospital, 2012-2013


Board Certifications

Surgery – Certified

Surgical Critical Care – Certified

Clinical Interests

Resuscitation, transfusion, trauma, critical care, emergent general surgery

Selected Publications

Walsh M, Shreve J, Thomas S, Moore E, Moore H, Hake D, Pohlman T, Davis P, Ploplis V, Piscoya A, Wegner J, Bryant J, Crepinseki A, Lantry J, Sheppard F, Castellino F.  Fibrinolysis in Trauma: “Myth”, “Reality”, or “Something in Between”.  Semin Thromb Hemost. 2017;43(2):200-212.

Macko A, Moore H, Cap A, Meledeo M, Moore E, Sheppard F. Tissue injury suppresses fibrinolysis following hemorrhagic shock in non-human primates (rhesus macaque). J Trauma Acute Care Surg. 2017 Jan 26. [Epub ahead of print]

Schaub L, Moore H, Cap A, Glaser J, Moore E, Sheppard F. Non-human primate model of poly-traumatic hemorrhagic shock recapitulates early platelet dysfunction observed following severe injury in humans.  J Trauma Acute Care Surg. 2016 Dec 23. [Epub ahead of print]

Vernon P, Paredes R, Sooter A, Schaub L, Grossman H, Pusateri A, Glaser J, Sheppard F. Severe hemorrhagic Shock Induces Acute Activation and Expansion of IL-8+/IL-10+ Neutrophils with Enhanced Oxidative Reactivity in Non-Human Primates. Shock 2016;46(3S):129-136.

Burdette A, Paredes R, Crossland F, Macko A, Aden J, Sheppard F. Inflammatory Profile in Response to Uncontrolled hemorrhage in a Non-Human Primate (Rhesus Macaque) Model. Shock 2016;46(3S):115-122.

Campbell J, Li Y, Van Amersfoort E, Relan A, Dubick M, Sheppard F, Pusateri A, Niemeyer D, Tsokos G, Dalle Lucca J. C1 Inhibitor Limits Organ Injury and Prolongs Survival in Swine Subjected to Battlefield Simulated Injury. Shock 2016;46(3S):177-188.

Crossland R, Mitchell A, Macko A, Aden J, Campbell J, Sheppard F.  Rapid Assessment of Shock in a Non-Human Primate Model of Uncontrolled Hemorrhage: Association of Traditional and Non-Traditional Vital Signs to Mortality Risk. Journal of Trauma and Acute Care Surgery 2016;80(4):610-616.

Macko A, Crossland R, Cap A, Fryer D, Mitchell T, Pusateri A, Sheppard F.  Control of Severe Intra-Abdominal Hemorrhage with an Infusible Platelet-Derived Hemostatic Agent in a Non-Human Primate (Rhesus Macaque) Model. Journal of Trauma and Acute Care Surgery 2016;80(4):617-624.

Vernon P, Schaub L, Dallelucca J, Pusateri A, Sheppard F. Rapid Detection of Neutrophil Oxidative Burst Capacity is Predictive of Whole Blood Cytokine Responses. PloS one 2015;10(12):e0146105.doi:10.1371/journal.pone.0146105

Dobson G, Letson H, Sharma R, Sheppard F, Cap A. "Mechanisms of early trauma-induced coagulopathy: The clot thickens or not?" Journal of Trauma and Acute Care Surgery 2015;79(2):301-309.

Campbell J, Oh T, Hurtgen B, Niemeyer D, Sheppard F, Dalle Lucca J. Blast Overpressure Induced Pulmonary and Intestinal Damage is Ameliorated by Post-injury Decay Accelerating Factor Injection.  J Clin Immunol Immunother 2015;2(1): 1-7.

Sheppard F, Macko A, Fryer D, Ozuna K, Brown A, Crossland R, Tadaki D. Development of a Non-Human Primate (Rhesus Macaque) Model of Uncontrolled Traumatic Liver Hemorrhage. Shock 2015;210:539-7005.

Sheppard F.  Fragments From Iraq: Diary of a Navy Trauma Surgeon. J Trauma Acute Care Surg. 2012 Oct;73(4):1031. (Book Review)

Alam H, Pusateri A, Kindzelski A, Egan D, Hoots K, Andrews M, Rhee P, Tisherman S, Mann K, Vostal J, Kochanek P, Scalea T, Deal V, Sheppard F, Sopko G. Hypothermia and Hemostasis in Severe Trauma: A New Crossroads Workshop Report. J Trauma Acute Care Surg. 2012 Oct;73(4):809-17.

Benfield R, Mamczak C, Vo K, Smith T, Osborne L, Sheppard F, Elster E. Initial Predictors Associated with Outcome in Injured Multiple Traumatic Limb Amputations: A Kandahar-Based Combat Hospital Experience. Injury. 2012 Oct;43(10):1753-8

Pub Med page for Forest R. Sheppard, MD