physician photo

Bradley D. Freeman, MD

  • Professor of Surgery

Medical School

Duke University, 1988

Post Doctoral Education

Internal Medicine - Duke University Medical Center, 1988-1991

General Surgery - Washington University Medical Center, 1991-1997

Critical Care - National Institutes of Health, 1993-1995

Board Certifications

General Surgery -- Certified 
Internal Medicine -- Certified 
Critical Care Medicine -- Certified

Clinical Interests

Dr. Freeman specializes in elective and emergency general surgery and trauma.

Research Interests

NIGMS, AHRQ, American College of Surgeons
Ethical considerations in the application of genetic technology to the care of the critically ill patient, use of clinical simulation in teaching and assessing clinical competency, and optimizing use of tracheostomy in the setting of acute respiratory failure.

Washington University Clinical Coordinator: "Burn and Trauma Injury Glue Grant," National Institutes of Health NIGMS, 2001-2006

Principal Investigator: "Pharmacogenetics in Surgical Critical Care," National Institutes of Health NIGMS, 2002-2005

Principal Investigator: "Establishing the Ethical Framework for Critical Care," National Institutes of Health, 2008-2013

Principal Investigator: "Early ICU Standardized Rehabilitation Therapy for the Critically Injured Burn Patient," Department of Defense, 2012-2015.

Principal Investigator: "A randomized, double-blind, placebo-controlled, multi-center, phase III study of IV Betafectin® PGG-Glucan for the prevention of serious infections in patients undergoing upper gastrointestinal surgery who are at high risk for infection," Alpha Beta Technology, Inc., 1998

Principal Investigator: "Linezolid (PNU-100766) in the treatement of patients with nosocomial pneumonia: a double blind, randomized, comparator-controlled study," Pharmacia and UpJohn, 1998-2000

Government - Consultant: "Crititcal Care Skills: Simulation to assess decision-making skills," National Institutes of Health, 2013-PRESENT.

Government - Principal Investigator Interim: Development of Automated FAST for Trauma," 2013-PRESENT.

Hospital Affiliations

Barnes-Jewish Hospital
Christian Hospital

Patients Seen At

Christian Hospital
Professional Building 1

11155 Dunn Road
St. Louis, MO 63136
Suite: 180N
Office Phone: 314-953-8300

Surgical and Wound Care Clinic
Barnes Center for Outpatient Health
4901 Forest Park Ave.
Floor 3, Suite 340
St. Louis, MO 63108
Fax: 314-362-5743

Contact Information

Barnes - Jewish Hospital
One Barnes-Jewish Hospital Plaza, Suite 14107
St. Louis, MO 63110
(314) 362-1064

Selected Publications

Winfield RD, Southard RE, Turnbull IR, Bochicchio K, Reese S, Freeman BD, Bochicchio GV. Angiotensin Inhibition is Associated with Preservation of T-Cell and Monocyte Function and Decreases Multiple Organ Failure in Obese Trauma Patients. J Am Coll Surg. 2015 Aug;221(2):486-494.

Jeschke MG, Pinto R, Kraft R, Nathens AB, Finnerty CC, Gamelli RL, Gibran NS, Klein MB, Arnoldo BD, Tompkins RG, Herndon DN; Inflammation and the Host Response to Injury Collaborative Research Program. Morbidity and survival probability in burn patients in modern burn care. Crit Care Med. 2015 Apr;43(4):808-15.

Freeman BD, Butler K, Bolcic-Jankovic D, Clarridge BR, Kennedy CR, LeBlanc J, Hull SC. Surrogate Receptivity to Participation in Critical Illness Genetic Research: Aligning Research Oversight and Stakeholder Concerns. Chest. 2015 Apr 1;147(4):979-88.

Shelton AK, Freeman BD, Fish AF, Bachman JA, Richardson LI. A computer-based education intervention to enhance surrogate informed consent for genomics research. Am J Crit Care. 2015 Mar;24(2):148-55.

Murray DJ, Freeman BD, Boulet JR, Woodhouse J, Fehr JJ, Klingensmith ME. Decision-Making in Trauma Settings: Simulation to Improve Diagnositc Skills. Simul Health. 2015 Feb 23. [Epub ahead of print]

Bolcic-Jancovic D, Clarridge B, LeBlanc J, Mahmood R, Roman AM, Freeman BD. Exploring determinates of surrogate decision maker confidence: an example from the ICU. J Empir Res Hum Res Ethics. 2014 Oct;9(4):76-85.

Freeman BD. Is it time to rethink postgraduate training requirements for licensure? Academic Medicine. (In Press)

Iverson E, Celious A, Kennedy C, Shehane E, Eastman A, Warren V, Freeman BD. Factors affecting stress experienced by surrogate decision-makers for critically ill patients: Implications for nursing practice. Intensive Critical Care Nursing. 2014 Apr;30(2):77-85.

Freeman BD, Stwalley D, Lambert D, Edler J, Medvedev S, Hohmann SF, Kymes SM. High resource utilization does not affect mortality in acute respiratory failure patients managed with tracheostomy. Respiratory Care. 2013 Nov;58(11):1995-6.

Leinicke JA, Elmore L, Freeman BD, Colditz GA. Operative management of rib fractures in the setting of flail chest: a systematic review and meta-analysis. Annals of Surgery. 2013;258:914-921.

Iverson E, Celious A, Kennedy CR, Shehane E, Eastman A, Warren V, Freeman BD. Perspectives of surrogate decision makers for critically ill patients regarding gene variation research. Genetics in Medicine. 2013;15(5):368-373.

Freeman BD, Morris PE. Concise Definitive Review: Tracheostomy practice in adults with acute respiratory failure. Critical Care Medicine. 2012;40:2890-2896.

Iverson E, Celious A, Kennedy CR, Shehane E, Eastman A, Warren V, Bolcic-Jankovic D, Clarridge B, Freeman BD. Real-time perspectives of surrogate decision makers regarding critical illness research - findings of focus group participants. Chest. 2012; 142(6):1433-1439.

Iverson E, Celious A, Shehane E, Kennedy CR, Oerke M, Warren V, Eastman A, Freeman BD. Brief Report: Critical Illness Research Involving Collection of Genomic Data - The conundrum posed by low levels of genomic literacy among surrogate decision-makers for critically ill patients. Journal of Empirical Research in Human Research Ethics. 2013 July;8(3):23-57.

Freeman BD, Kennedy CR, Bolcic-Jankovic D, Eastman A, Iverson E, Shehane E, Celious A, Barillas J, Clarridge B. Brief Report: Considerations in the construction of a quantative instrument to assess attitudes regarding critical illness genetic variation research. Journal of Empirical Research in Human Research Ethics. 2012;7(1):58-70.

Hamilton NA, Klieninger AN, Woodhouse J, Freeman BD, Murray D, Klingensmith ME. Video review improves team function in high-fidelity simulated trauma resuscitation. Journal of Surgical Eduction. 2012 May-June;69(3):428-31.

PubMed page for Bradley D. Freeman, MD.

Editorial Positions

Journal Reviewer

2000-Present, Journal of the American College of Surgeons
2000-Present, Critical Care Medicine
2000-Present, American Journal of Respiratory and Critical Care Medicine
2000-Present, Cochrane Database
2000-Present, Annals of Surgery
2000-Present, Respiratory Care
2000-Present, Surgical Infections


Sun J, Freeman BD, Natanson C. Using Secondary Data in Statistical Analysis in Principles and Practices in Clinical Research, 3rd ed, Gallin J (ed), Academic Press, 2012.

Rowland K, Freeman BD. Common Surgical Procedures. In: Klingensmith et al. (eds.). Washington University Manual of Surgery. 6th edition. Boston: Little, Brown and Co.; 2012.

Freeman BD. Indications for and Management of Tracheostomy. In: Abraham E et al. (eds.). Textbook of Critical Care. 5th edition. Philadelphia: W.B. Saunders Co.; 2011.

Freeman BD: Fluid and Electrolyte Abnormalities. In: Mulholland M, Doherty GM (eds.). Complications in Surgery. 2nd edition. Philadelphia: Lippincott, Williams and Wilkins; 2011

Freeman BD Commentary on "Genetic Influence on Response and Outcome" by O’Keefe, GE. In: Feliciano, Mattox, Moore (eds.). Trauma. New York: McGraw Hill, Inc.; 2008.

Freeman BD, Banks S, Natanson C. Using Secondary Data in Statistical Analysis. In: Gallin J (ed.). Principles and Practices in Clinical Research. 2nd edition. Academic Press; 2007.